Over the last two decades, one of the key discoveries in the field of medicine has been the finding that inflammation is not only part of some specific disorders but is partially or completely involved in a comprehensive range of diseases of mental or physical origin, and these health problems are among the most common causes of morbidity and mortality at present. This review discusses the chemical structure, toxicity, and current knowledge of the molecular mechanism of amygdalin activity on immune functions, including the anti-inflammatory effect, but also discusses inflammation as such, its mediators with diverse functions, which are usually targeted by drugs. Its pharmacological activities have been studied, but its effects on the body’s inflammatory response are lacking. Although amygdalin given at the correct oral dose may not lead to poisoning, it has not yet been accurately quantified, as its action is often affected by different intestinal microbial consortia. However, toxicity at different doses made it generally unacceptable.

This glycoside has already sparked many discussions among scientists, especially about its anticancer potential and related toxic cyanides. Amygdalin is a cyanogenic glycoside present, e.g., in bitter almonds.

Scientific research has therefore continued to explore new possibilities, including naturally available substances. Gradually, however, serious adverse side effects of such inhibitors became apparent. Therefore, there has been an effort to develop selective drugs aimed at removing pain, fever, or swelling.

This complicated reaction is controlled by regulatory mechanisms, some of which produce unpleasant symptomatic manifestations of inflammation. The inflammatory reaction accompanies in part or in full any disease process in the vascularized metazoan.

Hydroxocobalamin for cyanide poisoning